![]() ![]() This work demonstrated that the mechanistic dermal PK model fitted the clinical data well and was able to simulate the PK profile after patch misuse. affect cellular uptake and sub-compartment localization of HCQ, a base PK model of lysosomotropic agents like HCQ was applied. The final model was validated by confirming that the simulated concentration-time curves and PK parameters (C max and area under the drug plasma concentration-time curve) conformed to the observed values and then was used to simulate the PK profiles of rivastigmine. PK parameters were calculated using a NCA in Phoenix WinNonlin 6.3. The model was fitted to the clinical PK profiles after single application of rivastigmine patch to obtain model parameters. lipolysis model, whereas the firstpass extraction ratio can be assessed by. The initial values for the model were determined based on the physicochemical characteristics of rivastigmine and PK parameters after intravenous administration. The model comprised 2 compartments which was a combination of mechanistic dermal absorption model and a basic 1-compartment model. A dermal absorption pharmacokinetic (PK) model was developed to simulate the plasma concentration-time profile of rivastigmine to answer questions relative to the efficacy and safety risks after misuse of the patch (e.g., longer application than 24 h, multiple patches applied at the same time, and so forth). Rivastigmine is an inhibitor of acetylcholinesterases and butyrylcholinesterases for symptomatic treatment of Alzheimer disease and is available as oral and transdermal patch formulations. ![]()
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February 2023
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